Tim Burton, Michael Keaton and More Share How ‘Beetlejuice’ Sequel Came Together

If you wonder why it took 36 years for “Beetlejuice” to spawn a sequel, consider how complicated it was simply to reunite its busy principals for a video call last month.

The director Tim Burton joined from the south of France, where he was editing the second season of the Netflix series “Wednesday,” while Winona Ryder signed on from Atlanta, on a brief break from filming the final season of “Stranger Things.” Michael Keaton spent the call roaming a cabin he’d built in rural Montana — “I’m reheating coffee, if you want some,” he told the group — while Catherine O’Hara, the last to sign on, did so from her cottage in Ontario, Canada.

Still, even on a video call that catered to a torturous number of time zones, the quartet’s comic chemistry remained strong. Ryder said revisiting their decades-old bond was the best part of making “Beetlejuice Beetlejuice,” which opens the Venice Film Festival on Wednesday before its theatrical release Sept. 6.

“It was nostalgic, but not in any saccharine sense,” Ryder said. “It went straight to the heart.”

In the 1988 original, the newly dead couple Barbara and Adam Maitland (Geena Davis and Alec Baldwin) marshal all their ghostly might in an attempt to scare away the Deetzes, city slickers who’ve moved into their Connecticut house. Eccentric hauntings ensue, including a memorable dinner-party possession where Delia Deetz (O’Hara) lurches in time to Harry Belafonte’s “Day-O.” But when the Maitlands go looking for added firepower, they make the mistake of hiring Beetlejuice (Keaton), a trickster spirit who plays by his own rules and has romantic designs on the Deetzes’ daughter, the dark and morbid Lydia (Ryder).

The new film picks up decades later as Lydia, now the host of an exploitative paranormal-reality series, heads back home with her stepmother, Delia, and skeptical daughter, Astrid (Jenna Ortega), in tow. Meanwhile, Beetlejuice lies in wait, still pining for the goth girl that got away.