‘Common Side Effects’ Is a Stylish and Trippy Animated Thriller

The animated pharma thriller/stoner dramedy “Common Side Effects,” available on Max, is as rare and precious as the miraculous mushroom its hero, Marshall (Dave King), discovers in the jungle. Smarts, humor, style and perspective rarely align so harmoniously. Not a lot of shows have as much to say, and fewer still say it with such panache.

“Common” follows the open-shirted, tiny-mouthed environmentalist Marshall, who wants to protect the fragile habitat of the blue angel mushroom, a fungus that can heal seemingly everything. Everyone should be able to access its powers, Marshall says, and no one should be denied a lifesaving cure because of poverty.

But he’s up against a lot, including the D.E.A., the F.B.I., big pharma, fellow mycologists, backwoods hooligans, jailhouse power players and sometimes just his own naiveté. He reunites with his high school lab partner, Frances (Emily Pendergast), after he is booted from one of her boss’s speeches. Frances doesn’t admit to him that she works for Reutical, a pharmaceutical company that does every single bad thing Marshall abhors. They trust each other, even though they haven’t seen each other in years, and when Marshall is in peril, he calls her.

“Just two things to mention,” he says, panic rising in his voice. “Some people are following me, and I brought my tortoise.”

Frances is just as desperate as Marshall. Her mother has Alzheimer’s and is in a memory care facility that they can barely afford; her boyfriend is sort of a yutz; and she is always waist-deep in a crisis of conscience about working for Reutical. Should she try to help Marshall do things Marshall’s slapdash way, or might Reutical be in a better position to cultivate, test and distribute such a powerful drug?

Her boss, Rick (Mike Judge), takes her up to the company’s rooftop helipad to encourage her to stick with the corporate vision. “You’re with us now, the helicopter people,” he says. “We don’t worry about the down-there problems.” He doesn’t say it in an evil, cackling villain voice, though. He says it like an encouraging dad, like a mentor.