George Lowe, Kvetchy Voice of Cartoon Network’s Space Ghost, Dies at 67

George Lowe, the actor who voiced the superhero-turned-talk-show-host Space Ghost on “Space Ghost: Coast to Coast” on the Cartoon Network for nearly two decades, died on Sunday in Lakeland, Fla. He was 67.

His agent, Christy Clark, confirmed the death. His family said in a statement that Mr. Lowe had a challenging recovery after undergoing elective heart surgery in November.

“Space Ghost: Coast to Coast” was the first fully original program for Cartoon Network and the spark that led to the creation of Adult Swim, the network’s late-night programming block. The show, which ran for 11 seasons from 1994 until 2012, reimagined Space Ghost, the title character from a 1960s Hanna-Barbera superhero cartoon, as a temperamental talk show host, in a new format that mixed animation and live action.

Thanks to an enviable lineup of guests — Weird Al Yankovic, Beck and Sarah Jessica Parker were among the celebrities who made appearances — and decidedly off-the-wall interview questions (“Are you getting enough oxygen?” Space Ghost once asked Hulk Hogan), the show became a cult favorite among teenagers and young adults, helping launch Adult Swim into the stratosphere.

At the heart of it all was Mr. Lowe. Dave Willis, a writer and producer on the show, said Mr. Lowe had a “big, booming movie-trailer voice” and approached the role like the morning drive-time D.J. he had been before he got into voice work. His relatable and highly entertaining kvetching, Mr. Willis said, helped shape Space Ghost’s new persona.