Ketamine (Drug)

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    Matthew Perry’s Death Shines a Harsh Light on Ketamine Treatment

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    Was Mr. Perry, whose struggles with substance abuse were widely known, a good candidate for a drug used to relieve depression? Doctors say his case raises thorny questions.The actor Matthew Perry, who had long struggled with addiction, grew intrigued by ketamine a few years ago during a stay at a rehab facility in Switzerland where he received daily infusions of the powerful anesthetic “to ease pain and help with depression.”“Has my name written all over it — they might as well have called it ‘Matty,’” he later wrote of ketamine, which is known for its dissociative properties, in his 2022 memoir, “Friends, Lovers and the Big Terrible Thing.” It felt, he said, “like a giant exhale.”“As the music played and the K ran through me, it all became about the ego, and the death of the ego,” he wrote. “And I often thought that I was dying during that hour. Oh, I thought, this is what happens when you die.” As much as he was drawn to it, he wrote, he found the hangover unpleasant and ultimately decided that “ketamine was not for me.”But he eventually returned to the drug, getting ketamine treatments from doctors at clinics and then, as he grew addicted to it, buying it from illicit sources and getting multiple injections each day at his Los Angeles home, the authorities have said. On Oct. 28, after he received several shots from his personal assistant, he did die — face down in his hot tub. An autopsy determined that Mr. Perry had died from “the acute effects of ketamine,” with drowning one of several contributing factors.“Matthew Perry sought treatment for depression and anxiety and went to a local clinic where he became addicted to intravenous ketamine,” Anne Milgram, the head of the federal Drug Enforcement Administration, said at a news conference last week. “When clinic doctors refused to increase his dosage, he turned to unscrupulous doctors who saw Perry as a way to make quick money.”Drugs and paraphernalia connected to a person accused of distributing ketamine to Mr. Perry. While ketamine poses a lower addiction risk than opioids, it can produce an out-of-body experience that some people enjoy.U.S. District Court Central District, via Agence France-PresseWe are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      The Pain of Matthew Perry’s Last Days as He Relied on Ketamine

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      Court papers show that Mr. Perry, the “Friends” star who had long struggled with addiction, was increasingly taking ketamine, a powerful anesthetic, in the days before he died.On the day Matthew Perry died, his live-in personal assistant gave him his first ketamine shot of the morning at around 8:30 a.m. About four hours later, while Mr. Perry watched a movie at his home in Los Angeles, the assistant gave him another injection.It was only about 40 minutes later that Mr. Perry wanted another shot, the assistant, Kenneth Iwamasa, recalled in a plea agreement that he signed.“Shoot me up with a big one,” Mr. Perry told Mr. Iwamasa, according to the agreement, and asked him to prepare his hot tub.So Mr. Iwamasa filled a syringe with ketamine, gave his boss a third shot and left the house to run some errands, according to court papers. When he returned, he found Mr. Perry face down in the water, dead.Mr. Iwamasa was one of five people who the authorities in California said this week had been charged with a conspiracy to distribute ketamine, a powerful anesthetic, to Mr. Perry. The defendants also included two doctors, a woman accused of being a dealer and an acquaintance who pleaded guilty to acting as a middleman.Mr. Perry, a beloved figure who rose to fame playing Chandler Bing on the sitcom “Friends,” had long struggled with addiction. Court papers filed in the case shed light on the desperate weeks leading up to Mr. Perry’s death on Oct. 28 at the age of 54.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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      Matthew Perry’s Assistant and Doctors Charged With Getting Him Ketamine

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      Five people have been charged with a conspiracy to distribute the powerful anesthetic that led to the death of the “Friends” star. Three of them are pleading guilty.Matthew Perry’s personal assistant, two doctors and two others have been indicted and charged with providing the ketamine that caused his death.Jason LaVeris/FilmMagicMatthew Perry’s personal assistant, two doctors and two others have been indicted and charged with providing the ketamine that caused the death of Mr. Perry, a star on the television show “Friends,” the authorities said on Thursday.In documents filed in federal court in California, prosecutors said that Mr. Perry’s assistant and an acquaintance had worked with two doctors and a drug dealer to procure tens of thousands of dollars worth of ketamine for Mr. Perry, who had long struggled with substance abuse and addiction.The actor, who gained sitcom superstardom as Chandler Bing on “Friends,” was discovered floating face down in a hot tub at his home in Los Angeles on Oct. 28. The Los Angeles County medical examiner’s office said in an autopsy report that Mr. Perry, 54, had died of “acute effects of ketamine.”An indictment filed in federal court on Wednesday detailed grand jury charges against Jasveen Sangha, who prosecutors said was known as “the Ketamine Queen,” and Dr. Salvador Plasencia, known as “Dr. P.”Ms. Sangha maintained a “stash house” in North Hollywood, the indictment said, and Dr. Plasencia, a physician at an urgent care center, was among those who worked to get the ketamine to Mr. Perry despite knowing he had a history of drug abuse.Court documents say that Mr. Perry’s personal assistant, Kenneth Iwamasa, injected him with at least 27 shots of ketamine in the five days leading up to his death, including at least three on the day he died. An indictment said that the defendants used coded language to discuss drug deals, referring to bottles of ketamine as “Dr Pepper,” “cans” and “bots.” And it said that when Dr. Plasencia texted with another doctor about how much to charge Mr. Perry for ketamine, he wrote, “I wonder how much this moron will pay” and “Lets find out.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More