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    Matthew Perry’s Death Shines a Harsh Light on Ketamine Treatment

    Was Mr. Perry, whose struggles with substance abuse were widely known, a good candidate for a drug used to relieve depression? Doctors say his case raises thorny questions.The actor Matthew Perry, who had long struggled with addiction, grew intrigued by ketamine a few years ago during a stay at a rehab facility in Switzerland where he received daily infusions of the powerful anesthetic “to ease pain and help with depression.”“Has my name written all over it — they might as well have called it ‘Matty,’” he later wrote of ketamine, which is known for its dissociative properties, in his 2022 memoir, “Friends, Lovers and the Big Terrible Thing.” It felt, he said, “like a giant exhale.”“As the music played and the K ran through me, it all became about the ego, and the death of the ego,” he wrote. “And I often thought that I was dying during that hour. Oh, I thought, this is what happens when you die.” As much as he was drawn to it, he wrote, he found the hangover unpleasant and ultimately decided that “ketamine was not for me.”But he eventually returned to the drug, getting ketamine treatments from doctors at clinics and then, as he grew addicted to it, buying it from illicit sources and getting multiple injections each day at his Los Angeles home, the authorities have said. On Oct. 28, after he received several shots from his personal assistant, he did die — face down in his hot tub. An autopsy determined that Mr. Perry had died from “the acute effects of ketamine,” with drowning one of several contributing factors.“Matthew Perry sought treatment for depression and anxiety and went to a local clinic where he became addicted to intravenous ketamine,” Anne Milgram, the head of the federal Drug Enforcement Administration, said at a news conference last week. “When clinic doctors refused to increase his dosage, he turned to unscrupulous doctors who saw Perry as a way to make quick money.”Drugs and paraphernalia connected to a person accused of distributing ketamine to Mr. Perry. While ketamine poses a lower addiction risk than opioids, it can produce an out-of-body experience that some people enjoy.U.S. District Court Central District, via Agence France-PresseWe are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    The Pain of Matthew Perry’s Last Days as He Relied on Ketamine

    Court papers show that Mr. Perry, the “Friends” star who had long struggled with addiction, was increasingly taking ketamine, a powerful anesthetic, in the days before he died.On the day Matthew Perry died, his live-in personal assistant gave him his first ketamine shot of the morning at around 8:30 a.m. About four hours later, while Mr. Perry watched a movie at his home in Los Angeles, the assistant gave him another injection.It was only about 40 minutes later that Mr. Perry wanted another shot, the assistant, Kenneth Iwamasa, recalled in a plea agreement that he signed.“Shoot me up with a big one,” Mr. Perry told Mr. Iwamasa, according to the agreement, and asked him to prepare his hot tub.So Mr. Iwamasa filled a syringe with ketamine, gave his boss a third shot and left the house to run some errands, according to court papers. When he returned, he found Mr. Perry face down in the water, dead.Mr. Iwamasa was one of five people who the authorities in California said this week had been charged with a conspiracy to distribute ketamine, a powerful anesthetic, to Mr. Perry. The defendants also included two doctors, a woman accused of being a dealer and an acquaintance who pleaded guilty to acting as a middleman.Mr. Perry, a beloved figure who rose to fame playing Chandler Bing on the sitcom “Friends,” had long struggled with addiction. Court papers filed in the case shed light on the desperate weeks leading up to Mr. Perry’s death on Oct. 28 at the age of 54.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe. More

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    Death of David Gail, ‘Port Charles’ Star, Was Drug Related, Publicist Says

    The 58-year-old actor, who was also on “Beverly Hills, 90210,” died last month in a Tampa, Fla., hospital days after going into cardiac arrest.David Gail, the “Port Charles” and “Beverly Hills, 90210” actor who died in a Tampa, Fla. hospital on Jan. 16, had been intoxicated from a mix of drugs and alcohol that caused him to go into cardiac arrest, his publicist said on Tuesday.A number of drugs were found in Mr. Gail’s system, including amphetamines, cocaine, alcohol and fentanyl, according to a statement from the publicist, Linda Brown. The cardiac arrest led to a brain injury, which ultimately caused his death days later, she said.The Hillsborough County Medical Examiner did not immediately respond to a request for Mr. Gail’s autopsy report on Tuesday evening.The family previously said that Mr. Gail, 58, had died from complications from a sudden cardiac arrest.Paramedics who found Mr. Gail after he went into cardiac arrest performed CPR and used a defibrillator to try to revive him, but he ultimately wound up on life support at the hospital, according to Ms. Brown.Mr. Gail’s mother, Mary Painter, said in the statement that her son had for years been reliant on medication to manage pain from hand and wrist surgeries that kept him out of work for nearly a decade.“It breaks my heart to learn my son died this way,” Ms. Painter said, adding, “I can only assume that his former dependence played a part in self-medicating from uncontrolled sources.”Her son’s death, she said, highlighted victims of pharmaceutical addiction and the fentanyl epidemic.Mr. Gail had a bountiful television acting career in the mid- to late 1990s, including his most prominent role, as Dr. Joe Scanlon on the “General Hospital” spinoff show “Port Charles.” Mr. Gail played Dr. Scanlon in 216 episodes in one season, which ran in 1999 and 2000, according to IMDb.Years before that, Mr. Gail appeared on eight episodes of “Beverly Hills, 90210,” playing a minor part in an episode in the first season and returning to the show for the fourth season in a more established role.“When I came back it was such a shock, I was asking, ‘How could I possibly come back?’” Mr. Gail said about his return on the “Beverly Hills Show Podcast” in 2021.“But it worked,” he added.He also made dozens of appearances in a variety of television shows throughout the 1990s and several films in the 2000s. More

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    Mae Martin Embraces Ambiguity in ‘Feel Good,’ and in Life

    In an interview, the creator and star of the Netflix comedy discusses the hazy line between fact and fiction, the value of uncertainty and the joy of finally getting to be a leading man.Mae Martin didn’t set out to confront a throng of personal demons with the semi-autobiographical tragicomic Netflix series “Feel Good.” That’s just how it played out. More